Endocrine Abstracts

Mouse distal Chromosome 2 has a proximal region containing a single imprinted gene, Neuronatin, Nnat. In situ hybridisation has shown strong expression of neuronatin in the embryonic mouse Rathke's pouch and primordial anterior pituitary (Wijnholds et al 1995, Dev Biol 171:73-84) and has been proposed to participate in pituitary development. Uniparental maternal inheritance of the proximal region leads to decreased folding of the cerebellum (Kikyo et al 1997, Dev Biol 190:66-7...

Background: The anti-hyperglycemic effects of thiazolidinedione/biguanide combination therapy are well established. However, the impact of such therapy on other clinical risk factors for cardiovascular disease (CVD) has not been extensively reported.Objective: To evaluate the anti-hyperlipidemic effects of pioglitazone (PIO) and rosiglitazone (ROSI) used in combination with metformin (MET) in patients with type 2 diabetes, a multicenter, retrospective, r...

Background: The anti-hyperglycemic effects of thiazolidinedione/biguanide combination therapy are well established. However, the impact of such therapy on other clinical risk factors for cardiovascular disease (CVD) has not been extensively reported.Objective: To evaluate the anti-hyperlipidemic effects of pioglitazone (PIO) and rosiglitazone (ROSI) used in combination with metformin (MET) in patients with type 2 diabetes, a multicenter, retrospective, r...

We present two patients with unusual manifestations of sarcoidosis and review gonadal involvement in this rare but important disease. A 27 year old man presented to the Ophthalmologists at our hospital with a red eye. He was diagnosed with anterior uveitis and commenced on topical corticosteroids. Following discovery of a testicular mass, he underwent testicular ultrasonography which demonstrated bilateral hyperechoic lesions. Histological examination of an open surgical biops...

Objective: Succinate dehydrogenase B (SDHB) germline mutations are associated with predominantly extra-adrenal paraganglioma (PGLs) and high rates of metastatic disease. Bladder paragangliomas are a rare form of chromaffin cell tumours arising from the bladder wall. The aim of the study is to highlight the preponderance of bladder paragangliomas associated with SDHB gene mutations.Design: Retrospective case series.Patients: Five of...